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Search Results for " antiarrhythmic agent "

51

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6476	Dofetilide UK 68789,UK-68798,Tikosyn,多非利特	Potassium Channel	Membrane transporter/Ion channel
	Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T72323	Antiarrhythmic agent-1
	Antiarrhythmic agent-1 (示例 I) 是一种抗心律失常试剂，也是IKr 钾离子通道抑制剂 (IC50<1 μM)。
T23652	AFD-21 AFD21,NS-2 Class 1 antiarrhythmic agent
	AFD-21是一种 I 类抗心律失常药物。它在钠通道失活状态下与钠通道结合，对钠通道具有使用和电压依赖性抑制作用，其解结合率与具有中等动力学的I 类抗心律失常药物相当。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T24021	E 0747 E-0747,E0747
	E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.
T11099	Droxicainide	Others	Others
	Droxicainide 是一种抗心律失常剂。
T0249	N-Acetylprocainamide NAPA,Acecainide,乙酰普卡胺,N-乙酰普鲁卡因胺	Potassium Channel; Sodium Channel; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	N-Acetylprocainamide (NAPA) 是K+通道抑制剂，是第三代抗心律失常剂。
T12858	Bidisomide SC40230	Others	Others
	Bidisomide (SC40230) (SC40230) 属于 I 类抗心律失常剂。
T4539	Nicainoprol 尼卡普醇,RU-42924	Sodium Channel	Membrane transporter/Ion channel
	Nicainoprol (RU-42924) 是一种快速钠通道阻断剂，是有效的抗心律失常剂。
T7219	Flecainide acetate Flecainide (acetate),氟卡胺,R-818,醋酸洗必太	Sodium Channel	Membrane transporter/Ion channel
	Flecainide acetate (R-818) 是位于心脏的 Nav1.5钠离子通道的阻断剂，具有抗心律失常的作用。
T7505	Azimilide Dihydrochloride NE-10064 Dihydrochloride,盐酸阿齐利特	Potassium Channel	Membrane transporter/Ion channel
	Azimilide Dihydrochloride (NE-10064 Dihydrochloride) 是 I(Ks) 和 I(Kr) 抑制剂，具有抗心律失常活性。
T7198	E-4031 (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇	EGFR; Potassium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	E-4031是甲磺酰苯胺III 类抗心律失常药，选择性地阻断hERG 钾通道。
T60322	Procainamide Biocoryl,Novocainamide	DNA Methyltransferase	Chromatin/Epigenetic
	Procainamide (Novocainamide) 是 DNA 甲基转移酶 1 (DNMT1) 的特异性强效抑制剂。Procainamide 是一种 1A 类抗心律失常药物。Procainamide 具有研究癌症和心律失常的潜力。
T11353	Gallopamil Methoxyverapamil,戈洛帕米	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Gallopamil (Methoxyverapamil) 是一种苯烷基胺钙拮抗剂，以浓度依赖性方式抑制酸分泌 (IC50 = 10.9 μM)。Gallopamil 显示出抗心律失常和血管扩张剂的功效。
T13177	Taquidil
	Tocainide hydrochloride 是一种sodium channel 阻滞剂，它阻断神经膜中产生疼痛的病灶中的钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物，可有效抑制各种情况下的室性心律失常。
T6541	Ibutilide Fumarate Corvert Fumarate,U70226E,富马酸伊布利特	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。
T1144	Lidocaine hydrochloride Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis; ERK; NF-κB; MEK; Sodium Channel	Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB
	Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T25157	Bisaramil
	Bisaramil is a new class I antiarrhythmic agent.
T35114	WAY-123398 free base Way-123398,Way 123398,Way 123,398,Way123398,Way-123,398,Way123,398
	Way 123398 is a class III antiarrhythmic agent.
T12538	Prifuroline	Others	Others
	Prifuroline is an agent of antiarrhythmic.
T26033	RAC 109 RAC-109,RAC109
	RAC 109 is a chiral antiarrhythmic agent.
T32032	GYKI-23107 HCl GYKI23107,GYKI23,107,GYKI 23107,GYKI-23107,GYKI 23,107,GYKI-23,107
	GYKI-23107 is an antiarrhythmic agent with a local anesthetic activity.
T30607	Budiodarone ATI2042,ATI-2042,ATI 2042
	Budiodarone（ATI-2042）is a chemical analog of an antiarrhythmic drug and amiodarone. Budedalone is promising as an antiarrhythmic agent for the prevention of atrial fibrillation.
T26136	RS 2135 RS2135,RS-2135
	RS 2135 is a novel class I antiarrhythmic agent to inhibit ischemia-induced ventricular arrhythmias.
T70524	Tedisamil sesquifumarate
	Tedisamil sesquifumarate is an Antiarrhythmic Agent (K(sup +) Channel Blocker)
T20732	Lignocaine N-oxide
	Lignocaine N-oxide is a metabolite of Lidocaine, which is an antiarrhythmic and anesthetic agent.
T38434	(-)-(S)-Cibenzoline (-)-(S)-Cibenzoline,Escibenzoline
	Cibenzoline, also known as Escibenzoline, is the S(+)-enantiomer of Cibenzoline and functions as an antiarrhythmic agent.
T21370	Amiodarone Nexterone,胺碘酮,Amiodarona,Cordarone,Aratac,Amiodaronum
	Amiodarone is categorized as a class III antiarrhythmic agent and prolongs phase 3 of the cardiac action potential. It also has numerous other effects, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone chemic
T25755	Lorajmine Lorajmina
	Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.
T32030	GYKI-16638 HCl GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638
	GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h
T21373	Aprindine hydrochloride Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil
	Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.
T12087	Modecainide BMY 40327,MJ 14030	Others	Others
	Modecainide is metabolite of Encainide, is an antiarrhythmic agent.
T71021	Fendiline
	Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent.
T28567	Ro 22-9194 Ro-22-9194
	Ro 22-9194 is a class I antiarrhythmic agent. Ro 22-9194 (>=10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity and shortening of action potential duration in guinea-pig ventricular cells.
T4550L	Ajmaline hydrochloride
	Ajmaline hydrochloride is an alkaloid found in the root of Rauwolfia serpentina, and other plant sources. It is a class of Ia antiarrhythmic agent that apparently works by changing the shape and threshold of cardiac action potentials.
T33426	MK-142 dimethanesulfonate MK142,MK 142,MK-142
	MK-142 dimethyl sulfonate is a biologic active agent with antiarrhythmic properties, and the content of MK-142 is relatively high in cardiac muscle compared to that in skeletal muscle, indicating that the substance tested has a high affinity with cardiac
T21391	Flecainide Tambocor,Apocard,Flecainida,Flecainidum
	Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of
T60482	Pilsicainide
	Pilsicainide (SUN 1165 free acid)是一种有效的 Ic 类抗心律失常药。Pilsicainide 是一种有效的钠通道阻滞剂。
T62207	KVI-020
	KVI-020 是一种选择性的、口服具有活力的心房钾通道 Kv1.5 阻滞剂 (IC50: 480 nM)。KVI-020 对 hERG 表现出抑制作用 (IC50: 15100 nM)。 KVI-020 是一种有效的抗心律失常剂 (antiarrhythmic)，能够用于研究房颤 (AF)。
T36561	(3S)-hydroxy Quinidine
	(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-depe...
T25934	Pentisomide Pentisomidum
	Pentisomide 是一种抗心律失常的化合物，对去极化（Ia 和 Ic 类作用）和复极有显著作用。它可剂量依赖性地抑制缺血再灌注心律失常。Pentisomide 已进入治疗心律失常的 II 期临床试验。
T71122	Carsatrin (free base)
	Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin
T62942	Moricizine Hydrochloride
	Moricizine Hydrochloride (EN 313) 是一种口服具有活力的 I 类抗心律失常剂。Moricizine Hydrochloride 能够减少 0 相去极化的速率；提高 2 相和 3 相复极率，降低动作电位持续时间，减少有效不应期。
T70975	Carsatrin succinate
	Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi...
T63635	Quinate
	Quinate 是抗心律失常剂，是有效的、选择性的、口服具有活力的细胞色素 P450db (cytochrome P450db) 抑制剂，是一种有效的 K+通道 (K+channel) 阻断剂 (IC50: 19.9 μM)。Quinate 也能够用于研究疟疾。
T69119	Disopyramide HCl
	Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intrave...
T61517	Quinidine Monosulfate
	Quinidine Monosulfate 是一种抗心律失常剂。Quinidine Monosulfate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+通道 (K+channel) 的有效阻断剂，其 IC50值为 19.9 μM。Quinidine Monosulfate 也可用作疟疾的研究。
T60428	Cibenzoline
	Cibenzoline 是一种抗心律失常药，通过直接影响成孔 Kir6.2 亚基而不是 SUR1 亚基来抑制 KATP 通道。 Cibenzoline 几乎不具有抗胆碱能活性。 Cibenzoline 显着降低与心肌收缩力下降密切相关的LVPG。 Cibenzoline 具有研究肥厚型梗阻性心肌病的潜力[1][2]。
T60893	Ep vinyl quinidine
	Ep vinyl quinidine (3-Epiquinine) 是Quinidine 的一种乙烯基立体异构体。Quinidine 可用于研究疟疾，也是一种抗心律失常剂。Quinidine 是口服有效的、选择性细胞色素 P450db 抑制剂，以及钾通道的有效阻断剂，IC50值为 19.9 μM。

化合物

Cat.No: T6476

Synonym: UK 68789,UK-68798,Tikosyn,多非利特

Target: Potassium Channel

Antiarrhythmic agent-1

Cat.No: T72323

Cat.No: T23652

Synonym: AFD21,NS-2 Class 1 antiarrhythmic agent

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

Cat.No: T24021

Synonym: E-0747,E0747

Cat.No: T11099

Target: Others

N-Acetylprocainamide

Cat.No: T0249

Synonym: NAPA,Acecainide,乙酰普卡胺,N-乙酰普鲁卡因胺

Target: Potassium Channel, Sodium Channel, Drug Metabolite

Cat.No: T12858

Synonym: SC40230

Target: Others

Cat.No: T4539

Synonym: 尼卡普醇,RU-42924

Target: Sodium Channel

Flecainide acetate

Cat.No: T7219

Synonym: Flecainide (acetate),氟卡胺,R-818,醋酸洗必太

Target: Sodium Channel

Azimilide Dihydrochloride

Cat.No: T7505

Synonym: NE-10064 Dihydrochloride,盐酸阿齐利特

Target: Potassium Channel

Cat.No: T7198

Synonym: (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇

Target: EGFR, Potassium Channel

Cat.No: T60322

Synonym: Biocoryl,Novocainamide

Target: DNA Methyltransferase

Cat.No: T11353

Synonym: Methoxyverapamil,戈洛帕米

Target: Calcium Channel

Cat.No: T13177

Ibutilide Fumarate

Cat.No: T6541

Synonym: Corvert Fumarate,U70226E,富马酸伊布利特

Target: Calcium Channel, Sodium Channel

Lidocaine hydrochloride

Cat.No: T1144

Synonym: Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

Cat.No: T25157

WAY-123398 free base

Cat.No: T35114

Synonym: Way-123398,Way 123398,Way 123,398,Way123398,Way-123,398,Way123,398

Cat.No: T12538

Target: Others

Cat.No: T26033

Synonym: RAC-109,RAC109

Cat.No: T32032

Synonym: GYKI23107,GYKI23,107,GYKI 23107,GYKI-23107,GYKI 23,107,GYKI-23,107

Cat.No: T30607

Synonym: ATI2042,ATI-2042,ATI 2042

Cat.No: T26136

Synonym: RS2135,RS-2135

Tedisamil sesquifumarate

Cat.No: T70524

Lignocaine N-oxide

Cat.No: T20732

(-)-(S)-Cibenzoline

Cat.No: T38434

Synonym: (-)-(S)-Cibenzoline,Escibenzoline

Cat.No: T21370

Synonym: Nexterone,胺碘酮,Amiodarona,Cordarone,Aratac,Amiodaronum

Cat.No: T25755

Synonym: Lorajmina

Cat.No: T32030

Synonym: GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638

Aprindine hydrochloride

Cat.No: T21373

Synonym: Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil

Cat.No: T12087

Synonym: BMY 40327,MJ 14030

Target: Others

Cat.No: T71021

Cat.No: T28567

Synonym: Ro-22-9194

Ajmaline hydrochloride

Cat.No: T4550L

MK-142 dimethanesulfonate

Cat.No: T33426

Synonym: MK142,MK 142,MK-142

Cat.No: T21391

Synonym: Tambocor,Apocard,Flecainida,Flecainidum

Cat.No: T60482

Cat.No: T62207

(3S)-hydroxy Quinidine

Cat.No: T36561

Cat.No: T25934

Synonym: Pentisomidum

Carsatrin (free base)

Cat.No: T71122

Moricizine Hydrochloride

Cat.No: T62942

Carsatrin succinate

Cat.No: T70975

Cat.No: T63635

Disopyramide HCl

Cat.No: T69119

Quinidine Monosulfate

Cat.No: T61517

Cat.No: T60428

Ep vinyl quinidine

Cat.No: T60893

Cat. No.	Product Name	Target	Signaling Pathways
T1334	Hydroquinidine 奎宁树,氢化奎宁定,Hydroconchinine,Dihydroquinidine,Hydroconquinine,(+)-Hydroquinidine,Dihydroquinine	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Hydroquinidine ((+)-Hydroquinidine) 是 Quinidine(一种抗心律不齐药) 的衍生物。它能够延长 QT 间隔，表现出抗心律不齐活性。
T0792	(-)-Sparteine sulfate pentahydrate (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate,五水合硫酸司巴丁	Sodium Channel	Membrane transporter/Ion channel
	(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) 是一种生物碱，是钠通道抑制剂，属于1a 类抗心律失常药。
T7938	Quinidine 奎尼丁,奎宁树	Parasite	Microbiology/Virology
	Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。
T7853	(+)-Sparteine 鹰爪豆碱,(+)-鹰爪豆碱,Pachycarpine	AChR	Neuroscience
	(+)-Sparteine (Pachycarpine) 是从苏格兰扫帚中提取的一种生物碱，是钠通道阻滞剂和 1a 类抗心律失常剂。它在神经细胞中竞争性地抑制烟碱型乙酰胆碱受体活性，是神经节阻滞剂。
TMA2106	(-)-Sparteine	P450	Metabolism
	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
T3029	Sparteine sulfate 硫酸司巴丁,Depasan,Tocosimplex,Actospar	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Sparteine sulfate (Tocosimplex) 是一种 1a 类抗心律失常药和钠通道阻滞剂。它可以螯合二价钙和镁。
TN1412	Astringin trans-Astringin,白皮杉醇葡萄糖苷	IL Receptor; Others	Immunology/Inflammation; Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production.
T21266	Quinine sulfate
	Quinidine sulfate 是一种抗心律失常剂。Quinidine sulfate 是一种口服有效的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂。Quinidine sulfate 是 K+通道 (K+channel) 的有效阻断剂，IC50值为 19.9 μM。Quinidine sulfate 同时具有抗疟疾的研究潜力。

天然产物

Cat.No: T1334

Synonym: 奎宁树,氢化奎宁定,Hydroconchinine,Dihydroquinidine,Hydroconquinine,(+)-Hydroquinidine,Dihydroquinine

Target: Potassium Channel, Sodium Channel

(-)-Sparteine sulfate pentahydrate

Cat.No: T0792

Synonym: (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate,五水合硫酸司巴丁

Target: Sodium Channel

Cat.No: T7938

Synonym: 奎尼丁,奎宁树

Target: Parasite

Cat.No: T7853

Synonym: 鹰爪豆碱,(+)-鹰爪豆碱,Pachycarpine

Target: AChR

Cat.No: TMA2106

Target: P450

Sparteine sulfate

Cat.No: T3029

Synonym: 硫酸司巴丁,Depasan,Tocosimplex,Actospar

Target: Others, Sodium Channel

Cat.No: TN1412

Synonym: trans-Astringin,白皮杉醇葡萄糖苷

Target: IL Receptor, Others

Quinine sulfate

Cat.No: T21266

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